Publications at Chuo University (since 2017)

2021

  1. H. Takeshita, T. Sugai, H. Fuwa
    Stereoselective synthesis of the southern hemisphere acyclic domain of neaumycin B
    The Journal of Organic Chemistry, 86, xxxx-xxxx (2021).
  2. K. Nishimura, R. Hanzawa, T. Sugai, H. Fuwa
    Ruthenium-catalyzed intramolecular double hydrofunctionalization of alkynes. Synthesis of spirocyclic hemiaminal ethers and their Lewis acid-mediated cleavage/nucleophilic addition
    The Journal of Organic Chemistry, 86, xxxx-xxxx (2021).
  3. M. Ohta, S. Kato, T. Sugai, H. Fuwa
    Cobalt-catalyzed Hartung-Mukaiyama cyclization of γ-hydroxy olefins: Stereocontrolled synthesis of the tetrahydrofuran moiety of amphidinolide N
    The Journal of Organic Chemistry, 86, xxxx-xxxx (2021).
  4. S. Kato, D. Mizukami, T. Sugai, M. Tsuda, H. Fuwa
    Total synthesis and complete configurational assignment of amphirionin-2
    Chemical Science, 21, 872-879 (2021).
    This article was featured on the inside cover.
    This article was selected as a ChemSci Pick/Chemical Science HOT Article Collection article.
    This article was featured in ChemistryViews "First Total Synthesis of Amphirionin-2"
  5. T. Sugai, H. Fuwa
    Total synthesis of (−)-enigmazole A
    Topics in Heterocyclic Chemistry, Marine Natural Products, Vol. xx, pp. xxx-xxx (2021).

2020

  1. K. Sakurai, K. Sakamoto, M. Sasaki, H. Fuwa
    Unified total synthesis of (−)-enigmazole A and (−)-15-O-methylenigmazole A
    Chemistry - An Asian Journal, 15, 3494-3502 (2020).
  2. K. Murata, H. Takeshita, K. Sakamoto, H. Fuwa
    Tandem three-component synthesis of syn-1,2- and syn-1,3-diol derivatives
    Chemistry - An Asian Journal, 15, 807-819 (2020).
    Invited contribution to the special issue for the anniversary of the 100th annual meeting of the Chemical Society of Japan.
  3. J. Molgó, S. Schlumberger, M. Sasaki, H. Fuwa, M. C. Louzao, L. M. Botana, D. Servent, E. Benoit
    Gambierol potently increases evoked quantal transmitter release and reverses pre-and post-synaptic blockade at vertebrate neuromuscular junctions
    Neuroscience, 439, 106-116 (2020).
  4. 村田佳亮、不破春彦
    タンデム反応と複雑天然物の全合成
    化学工業, 71, 117-124 (2020).

2019

  1. S. Yanagi, T. Sugai, T. Noguchi, M. Kawakami, M. Sasaki, S. Niwa, A. Sugimoto, H. Fuwa
    Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging
    Organic & Biomolecular Chemistry, 17, 6771-6776 (2019).
  2. K. Sakamoto, A. Hakamata, A. Iwasaki, K. Suenaga, M. Tsuda, H. Fuwa
    Total synthesis, stereochemical revision, and biological assessment of iriomoteolide-2a
    Chemistry - A European Journal, 25, 8528-8542 (2019).
    This paper was selected as VIP "Very Important Paper".
    This paper was featured on the Inside Cover.
  3. K. Murata, K. Sakamoto, H. Fuwa
    Stereoselective tandem synthesis of syn-1,3-diol derivatives by integrating olefin cross-metathesis, hemiacetalization, and intramolecular oxa-Michael addition
    Organic Letters, 21, 3730-3734 (2019).
  4. 坂本渓太、不破春彦
    海洋マクロリド天然物iriomoteolide-2aの全合成：複雑な天然物の構造決定と生物活性評価における全合成の役割
    有機合成化学協会誌, 77, 831-840 (2019).

2018

  1. K. Iio, S. Sachimori, T. Watanabe, H. Fuwa
    Ruthenium-catalyzed intramolecular double hydroalkoxylation of internal alkynes
    Organic Letters, 20, 7851-7855 (2018).
  2. K. Sakurai, M. Sasaki, H. Fuwa
    Total synthesis of (−)-enigmazole A
    Angewandte Chemie, International Edition, 57, 5143-5146 (2018).
    This paper was featured in SYNFACTS.
  3. K. Sakamoto, A. Hakamata, M. Tsuda, H. Fuwa
    Total synthesis and stereochemical revision of iriomoteolide-2a
    Angewandte Chemie, International Edition, 57, 3801-3805 (2018).
  4. 不破春彦、坂本渓太
    プレウロムチリンの全合成ー独創的な合成戦略から垣間見えること
    化学, 73 (6), 66-67 (2018).
  5. 不破春彦、佐々木誠
    ガンビエロール構造簡略体の設計・合成・生物機能
    CSJカレントレビュー27 天然有機化合物の全合成：独創的なものづくりの反応と戦略, 化学同人 (2018).

2017

  1. H. Fuwa, M. Sato
    A synthetic analogue of neopeltolide, 8,9-dehydroneopeltolide, is a potent anti-austerity agent against starved tumor cells
    Marine Drugs, 15, 320 (2017).
    This article was written on invitation from Editor and selected as "Featured Article".
  2. E. Alonso, A. C. Vieira, I. Rodriguez, R. Alvarino, S. Gegunde, H. Fuwa, Y. Suga, M. Sasaki, A. Alfonso, J. M. Cifuentes, L. M. Botana
    Tetracyclic truncated analogue of the marine toxin gambierol modifies NMDA, Tau, and amyloid beta expression in mice brains: Implications in AD pathology
    ACS Chemical Neuroscience, 8, 1358-1367 (2017).

Publications at Tohoku University (2012-2016)

A full list of HF's publications, including those before 2012, is available here.

2016

  1. Y. Onodera, K. Hirota, Y. Suga, K. Konoki, M. Yotsu-Yamashita, M. Sasaki, H. Fuwa
    Diastereoselective ring-closing metathesis as a means to construct medium-sized cyclic ethers: Application to the synthesis of a photoactivatable gambierol derivative
    The Journal of Organic Chemistry, 81, 8234-8252 (2016).
  2. S. Furumochi, T. Onoda, Y. Cho, H. Fuwa, M. Sasaki, M. Yotsu-Yamashita, K. Konoki
    Effect of carbon chain length in acyl coenzyme A on the efficiency of enzymatic transformation of okadaic acid to 7-O-acyl okadaic acid
    Bioorganic & Medicinal Chemistry Letters, 26, 2992-2996 (2016).
  3. H. Fuwa, N. Yamagata, Y. Okuaki, Y. Ogata, A. Saito, M. Sasaki
    Total synthesis and complete stereostructure of a marine macrolide glycoside, (−)-lyngbyaloside B
    Chemistry - A European Journal, 22, 6815-6829 (2016).
    This article was selected as "Hot Paper".
    This article was featured on the Front Cover.
  4. Y. Kawashima, A. Toyoshima, H. Fuwa, M. Sasaki
    Toward the total synthesis of amphidinolide N: Synthesis of the C8–C29 fragment
    Organic Letters, 18, 2232-2235 (2016).
  5. R. Isaka, L. Yu, M. Sasaki, Y. Igarashi, H. Fuwa
    Complete stereochemical assignment of campechic acids A and B
    The Journal of Organic Chemistry, 81, 3638-3647 (2016).
  6. H. Fuwa, S. Matsukida, T. Miyoshi, Y. Kawashima, T. Saito, M. Sasaki
    Progress toward the total synthesis of goniodomin A: Stereocontrolled, convergent synthesis of the C12–C36 fragment
    The Journal of Organic Chemistry, 81, 2213-2227 (2016).
    This article was selected as "JOC Featured Article".
    This article was featured on the Front Cover.
  7. H. Fuwa, M. Sasaki
    Exploiting ruthenium carbene-catalyzed reactions in total synthesis of marine oxacyclic natural products
    Bulletin of the Chemical Society of Japan, 89, 1403-1415 (2016).
    This article was written on invitation from the Editor-in-Chief.
  8. H. Fuwa
    Contemporary strategies for the synthesis of tetrahydropyran derivatives: Application to total synthesis of neopeltolide, a marine macrolide natural product
    Marine Drugs, 14, 65 (2016).
    This article was written on invitation from Editor.
    This article was selected as "Featured Article".

2015

  1. H. Fuwa, K. Sakamoto, T. Muto, M. Sasaki
    Concise synthesis of the C15–C38 fragment of okadaic acid, a specific inhibitor of protein phosphatases 1 and 2A
    Tetrahedron, 71, 6369-6383 (2015).
    This article was written on invitation from Editor (Professor Jiro Tsuji Special Issue).
  2. J. A. Rubiolo, C. Vale, V. Martin, H. Fuwa, M. Sasaki, L. M. Botana
    Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation
    Archives of Toxicology, 89, 1119-1134 (2015).
  3. K. Konoki, Y. Suga, H. Fuwa, M. Yotsu-Yamashita, M. Sasaki
    Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity
    Bioorganic & Medicinal Chemistry Letters, 25, 514-518 (2015).
  4. H. Fuwa, K. Sakamoto, T. Muto, M. Sasaki
    Concise synthesis of the C15–C38 fragment of okadaic acid: Application of the Suzuki–Miyaura reaction to spiroacetal synthesis
    Organic Letters, 17, 366-369 (2015).
  5. H. Fuwa, R. Fukazawa, M. Sasaki
    Concise synthesis of the A/BCD-ring fragment of gambieric acid A
    Frontiers in Chemistry, 2, 116 (2015).
  6. H. Fuwa, Y. Okuaki, N. Yamagata, M. Sasaki
    Total synthesis, stereochemical reassignment, and biological evaluation of (−)-lyngbyaloside B
    Angewandte Chemie, International Edition, 54, 868-873 (2015).

2014

  1. H. Fuwa, M. Sato, M. Sasaki
    Programmed cell death induced by (−)-8,9-dehydroneopeltolide in human promyelocytic leukemia HL-60 cells under energy stress conditions
    Marine Drugs, 12, 5576-5589 (2014).
  2. H. Fuwa, T. Noguchi, M. Kawakami, M. Sasaki
    Synthesis and biological evaluation of (+)-neopeltolide analogues: Importance of the oxazole-containing side chain
    Bioorganic & Medicinal Chemistry Letters, 24, 2415-2419 (2014).
  3. H. Fuwa, T. Muto, K. Sekine, M. Sasaki
    Total synthesis and structure revision of didemnaketal B
    Chemistry - A European Journal, 20, 1848-1860 (2014).
    This article was featured on the Frontispiece.
  4. Y. Suga, H. Fuwa, M. Sasaki
    Stereoselective synthesis of medium-sized cyclic ethers: Application of C-glycosylation chemistry to seven- to nine-membered lactone-derived thioacetals and their sulfone counterparts
    The Journal of Organic Chemistry, 79, 1656-1682 (2014).
  5. M. Sasaki, H. Fuwa
    Total synthesis and complete structural assignment of gambieric acid A, a large polycyclic ether marine natural product
    The Chemical Record, 14, 678-803 (2014).
    This article was written on invitation from Editor.

2013

  1. H. Fuwa, M. Kawakami, K. Noto, M. Sasaki
    Synthesis and biological evaluation of aspergillide A/neopeltolide chimeras
    Chemistry Letters, 42, 1020-1022 (2013).
  2. H. Fuwa, K. Sekine, M. Sasaki
    Total synthesis of the proposed structure of didemnaketal B
    Organic Letters, 15, 3970-3973 (2013).
  3. H. Fuwa, M. Kawakami, K. Noto, T. Muto, Y. Suga, K. Konoki, M. Yotsu-Yamashita, M. Sasaki
    Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: Identification of pharmacophoric elements
    Chemistry - A European Journal, 19, 8100-8110 (2013).
  4. H. Fuwa, K. Mizunuma, M. Sasaki, T. Suzuki, H. Kubo
    Total synthesis and biological evaluation of (−)-exiguolide analogues: importance of the macrocyclic backbone
    Organic & Biomolecular Chemistry, 11, 3442-3450 (2013).
    This article was featured on the Back Cover.
  5. H. Fuwa, N. Yamagata, A. Saito, M. Sasaki
    Total Synthesis of 13-Demethyllyngbyaloside B
    Organic Letters, 15, 1630-1633 (2013).
  6. K. Ishigai, H. Fuwa, K. Hashizume, R. Fukazawa, Y. Cho, M. Yotsu-Yamashita, M. Sasaki
    Total synthesis and biological evaluation of (+)-gambieric acid A and its analogues
    Chemistry - A European Journal, 19, 5276-5288 (2013).
    This article was selected as VIP "Very Important Paper".
    This article was featured on the Front cover.

2012

  1. H. Fuwa, K. Hirota, M. Sasaki
    A concise synthesis of the AB-ring fragment of (−)-gambierol
    Heterocycles, 86, 127-132 (2012).
    This article was written on invitation from Editor (Prof. Ei-ichi Negishi Special Issue).
  2. H. Fuwa, T. Noguchi, K. Noto, M. Sasaki
    Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization: concise synthesis of 2,6-cis-substituted tetrahydropyran derivatives
    Organic & Biomolecular Chemistry, 10, 8108-8112 (2012).
  3. M. Nakajima, H. Fuwa, M. Sasaki
    Stereoselective synthesis of the C1–C16 fragment of goniodomin A
    Bulletin of the Chemical Society of Japan, 85, 948-956 (2012).
    This article was selected as "Selected Paper".
  4. S. Perez, C. Vale, E. Alonso, H. Fuwa, M. Sasaki, Y. Konno, T. Goto, Y. Suga, M. R. Vieytes, L. M. Botana
    Effect of gambierol and its tetracyclic and heptacyclic analogues in cultured cerebellar neurons: A structure–activity relationships study
    Chemical Research in Toxicology, 25, 1929-1937 (2012).
  5. H. Fuwa, K. Ishigai, K. Hashizume, M. Sasaki
    Total synthesis and complete stereostructure of gambieric acid A
    Journal of the American Chemical Society, 134, 11984-11987 (2012).
    This article was featured in SYNFACTS.
  6. E. Alonso, H. Fuwa, C. Vale, Y. Suga, T. Goto, Y. Konno, M. Sasaki, F. M. LaFerla, M. R. Vieytes, L. Gimenez-Llort, L. M. Botana
    Design and synthesis of skeletal analogues of gambierol: Attenuation of amyloid-β and Tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications
    Journal of the American Chemical Society, 134, 7467-7479 (2012).
  7. H. Fuwa, N. Ichinokawa, K. Noto, M. Sasaki
    Stereoselective synthesis of 2,6-cis-substituted tetrahydropyrans: Brønsted acid-catalyzed intramolecular oxa-conjugate cyclization of α,β-unsaturated ester surrogates
    The Journal of Organic Chemistry, 77, 2588-2607 (2012).
    This article was selected as "JOC Featured Article".
    This article was featured on the Front Cover.
  8. H. Fuwa
    Total synthesis of tetrahydropyran-containing natural products exploiting intramolecular oxa-conjugate cyclization
    Heterocycles, 85, 1255-1298 (2012).
    This article was written on invitation from Editor.