Publications at Chuo University (since 2017)
2021
- S. Kato, D. Mizukami, T. Sugai, M. Tsuda, H. Fuwa
Total synthesis and complete configurational assignment of amphirionin-2
Chemical Science, xx, xxxx-xxxx (2021).
This article was selected as a ChemSci Pick/Chemical Science HOT Article Collection article.
This article was featured in ChemistryViews "First Total Synthesis of Amphirionin-2"
- T. Sugai, H. Fuwa
Total synthesis of (−)-enigmazole A
Topics in Heterocyclic Chemistry, Marine Natural Products, Vol. xx, pp. xxx-xxx (2021).
2020
- K. Sakurai, K. Sakamoto, M. Sasaki, H. Fuwa
Unified total synthesis of (−)-enigmazole A and (−)-15-O-methylenigmazole A
Chemistry - An Asian Journal, 15, 3494-3502 (2020).
- K. Murata, H. Takeshita, K. Sakamoto, H. Fuwa
Tandem three-component synthesis of syn-1,2- and syn-1,3-diol derivatives
Chemistry - An Asian Journal, 15, 807-819 (2020).
Invited contribution to the special issue for the anniversary of the 100th annual meeting of the Chemical Society of Japan.
- J. Molgó, S. Schlumberger, M. Sasaki, H. Fuwa, M. C. Louzao, L. M. Botana, D. Servent, E. Benoit
Gambierol potently increases evoked quantal transmitter release and reverses pre-and post-synaptic blockade at vertebrate neuromuscular junctions
Neuroscience, 439, 106-116 (2020).
- 村田佳亮、不破春彦
タンデム反応と複雑天然物の全合成
化学工業, 71, 117-124 (2020).
2019
- S. Yanagi, T. Sugai, T. Noguchi, M. Kawakami, M. Sasaki, S. Niwa, A. Sugimoto, H. Fuwa
Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging
Organic & Biomolecular Chemistry, 17, 6771-6776 (2019).
- K. Sakamoto, A. Hakamata, A. Iwasaki, K. Suenaga, M. Tsuda, H. Fuwa
Total synthesis, stereochemical revision, and biological assessment of iriomoteolide-2a
Chemistry - A European Journal, 25, 8528-8542 (2019).
This paper was selected as VIP "Very Important Paper".
This paper was featured on the Inside Cover.
- K. Murata, K. Sakamoto, H. Fuwa
Stereoselective tandem synthesis of syn-1,3-diol derivatives by integrating olefin cross-metathesis, hemiacetalization, and intramolecular oxa-Michael addition
Organic Letters, 21, 3730-3734 (2019).
- 坂本渓太、不破春彦
海洋マクロリド天然物iriomoteolide-2aの全合成:複雑な天然物の構造決定と生物活性評価における全合成の役割
有機合成化学協会誌, 77, 831-840 (2019).
2018
- K. Iio, S. Sachimori, T. Watanabe, H. Fuwa
Ruthenium-catalyzed intramolecular double hydroalkoxylation of internal alkynes
Organic Letters, 20, 7851-7855 (2018).
- K. Sakurai, M. Sasaki, H. Fuwa
Total synthesis of (−)-enigmazole A
Angewandte Chemie, International Edition, 57, 5143-5146 (2018).
This paper was featured in SYNFACTS.
- K. Sakamoto, A. Hakamata, M. Tsuda, H. Fuwa
Total synthesis and stereochemical revision of iriomoteolide-2a
Angewandte Chemie, International Edition, 57, 3801-3805 (2018).
- 不破春彦、坂本渓太
プレウロムチリンの全合成ー独創的な合成戦略から垣間見えること
化学, 73 (6), 66-67 (2018).
- 不破春彦、佐々木誠
ガンビエロール構造簡略体の設計・合成・生物機能
CSJカレントレビュー27 天然有機化合物の全合成:独創的なものづくりの反応と戦略, 化学同人 (2018).
2017
- H. Fuwa, M. Sato
A synthetic analogue of neopeltolide, 8,9-dehydroneopeltolide, is a potent anti-austerity agent against starved tumor cells
Marine Drugs, 15, 320 (2017).
This article was written on invitation from Editor and selected as "Featured Article".
- E. Alonso, A. C. Vieira, I. Rodriguez, R. Alvarino, S. Gegunde, H. Fuwa, Y. Suga, M. Sasaki, A. Alfonso, J. M. Cifuentes, L. M. Botana
Tetracyclic truncated analogue of the marine toxin gambierol modifies NMDA, Tau, and amyloid beta expression in mice brains: Implications in AD pathology
ACS Chemical Neuroscience, 8, 1358-1367 (2017).
Publications at Tohoku University (2012-2016)
A full list of HF's publications, including those before 2012, is available
here.
2016
- Y. Onodera, K. Hirota, Y. Suga, K. Konoki, M. Yotsu-Yamashita, M. Sasaki, H. Fuwa
Diastereoselective ring-closing metathesis as a means to construct medium-sized cyclic ethers: Application to the synthesis of a photoactivatable gambierol derivative
The Journal of Organic Chemistry, 81, 8234-8252 (2016).
- S. Furumochi, T. Onoda, Y. Cho, H. Fuwa, M. Sasaki, M. Yotsu-Yamashita, K. Konoki
Effect of carbon chain length in acyl coenzyme A on the efficiency of enzymatic transformation of okadaic acid to 7-O-acyl okadaic acid
Bioorganic & Medicinal Chemistry Letters, 26, 2992-2996 (2016).
- H. Fuwa, N. Yamagata, Y. Okuaki, Y. Ogata, A. Saito, M. Sasaki
Total synthesis and complete stereostructure of a marine macrolide glycoside, (−)-lyngbyaloside B
Chemistry - A European Journal, 22, 6815-6829 (2016).
This article was selected as "Hot Paper".
This article was featured on the Front Cover.
- Y. Kawashima, A. Toyoshima, H. Fuwa, M. Sasaki
Toward the total synthesis of amphidinolide N: Synthesis of the C8–C29 fragment
Organic Letters, 18, 2232-2235 (2016).
- R. Isaka, L. Yu, M. Sasaki, Y. Igarashi, H. Fuwa
Complete stereochemical assignment of campechic acids A and B
The Journal of Organic Chemistry, 81, 3638-3647 (2016).
- H. Fuwa, S. Matsukida, T. Miyoshi, Y. Kawashima, T. Saito, M. Sasaki
Progress toward the total synthesis of goniodomin A: Stereocontrolled, convergent synthesis of the C12–C36 fragment
The Journal of Organic Chemistry, 81, 2213-2227 (2016).
This article was selected as "JOC Featured Article".
This article was featured on the Front Cover.
- H. Fuwa, M. Sasaki
Exploiting ruthenium carbene-catalyzed reactions in total synthesis of marine oxacyclic natural products
Bulletin of the Chemical Society of Japan, 89, 1403-1415 (2016).
This article was written on invitation from the Editor-in-Chief.
- H. Fuwa
Contemporary strategies for the synthesis of tetrahydropyran derivatives: Application to total synthesis of neopeltolide, a marine macrolide natural product
Marine Drugs, 14, 65 (2016).
This article was written on invitation from Editor.
This article was selected as "Featured Article".
2015
- H. Fuwa, K. Sakamoto, T. Muto, M. Sasaki
Concise synthesis of the C15–C38 fragment of okadaic acid, a specific inhibitor of protein phosphatases 1 and 2A
Tetrahedron, 71, 6369-6383 (2015).
This article was written on invitation from Editor (Professor Jiro Tsuji Special Issue).
- J. A. Rubiolo, C. Vale, V. Martin, H. Fuwa, M. Sasaki, L. M. Botana
Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation
Archives of Toxicology, 89, 1119-1134 (2015).
- K. Konoki, Y. Suga, H. Fuwa, M. Yotsu-Yamashita, M. Sasaki
Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity
Bioorganic & Medicinal Chemistry Letters, 25, 514-518 (2015).
- H. Fuwa, K. Sakamoto, T. Muto, M. Sasaki
Concise synthesis of the C15–C38 fragment of okadaic acid: Application of the Suzuki–Miyaura reaction to spiroacetal synthesis
Organic Letters, 17, 366-369 (2015).
- H. Fuwa, R. Fukazawa, M. Sasaki
Concise synthesis of the A/BCD-ring fragment of gambieric acid A
Frontiers in Chemistry, 2, 116 (2015).
- H. Fuwa, Y. Okuaki, N. Yamagata, M. Sasaki
Total synthesis, stereochemical reassignment, and biological evaluation of (−)-lyngbyaloside B
Angewandte Chemie, International Edition, 54, 868-873 (2015).
2014
- H. Fuwa, M. Sato, M. Sasaki
Programmed cell death induced by (−)-8,9-dehydroneopeltolide in human promyelocytic leukemia HL-60 cells under energy stress conditions
Marine Drugs, 12, 5576-5589 (2014).
- H. Fuwa, T. Noguchi, M. Kawakami, M. Sasaki
Synthesis and biological evaluation of (+)-neopeltolide analogues: Importance of the oxazole-containing side chain
Bioorganic & Medicinal Chemistry Letters, 24, 2415-2419 (2014).
- H. Fuwa, T. Muto, K. Sekine, M. Sasaki
Total synthesis and structure revision of didemnaketal B
Chemistry - A European Journal, 20, 1848-1860 (2014).
This article was featured on the Frontispiece.
- Y. Suga, H. Fuwa, M. Sasaki
Stereoselective synthesis of medium-sized cyclic ethers: Application of C-glycosylation chemistry to seven- to nine-membered lactone-derived thioacetals and their sulfone counterparts
The Journal of Organic Chemistry, 79, 1656-1682 (2014).
- M. Sasaki, H. Fuwa
Total synthesis and complete structural assignment of gambieric acid A, a large polycyclic ether marine natural product
The Chemical Record, 14, 678-803 (2014).
This article was written on invitation from Editor.
2013
- H. Fuwa, M. Kawakami, K. Noto, M. Sasaki
Synthesis and biological evaluation of aspergillide A/neopeltolide chimeras
Chemistry Letters, 42, 1020-1022 (2013).
- H. Fuwa, K. Sekine, M. Sasaki
Total synthesis of the proposed structure of didemnaketal B
Organic Letters, 15, 3970-3973 (2013).
- H. Fuwa, M. Kawakami, K. Noto, T. Muto, Y. Suga, K. Konoki, M. Yotsu-Yamashita, M. Sasaki
Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: Identification of pharmacophoric elements
Chemistry - A European Journal, 19, 8100-8110 (2013).
- H. Fuwa, K. Mizunuma, M. Sasaki, T. Suzuki, H. Kubo
Total synthesis and biological evaluation of (−)-exiguolide analogues: importance of the macrocyclic backbone
Organic & Biomolecular Chemistry, 11, 3442-3450 (2013).
This article was featured on the Back Cover.
- H. Fuwa, N. Yamagata, A. Saito, M. Sasaki
Total Synthesis of 13-Demethyllyngbyaloside B
Organic Letters, 15, 1630-1633 (2013).
- K. Ishigai, H. Fuwa, K. Hashizume, R. Fukazawa, Y. Cho, M. Yotsu-Yamashita, M. Sasaki
Total synthesis and biological evaluation of (+)-gambieric acid A and its analogues
Chemistry - A European Journal, 19, 5276-5288 (2013).
This article was selected as VIP "Very Important Paper".
This article was featured on the Front cover.
2012
- H. Fuwa, K. Hirota, M. Sasaki
A concise synthesis of the AB-ring fragment of (−)-gambierol
Heterocycles, 86, 127-132 (2012).
This article was written on invitation from Editor (Prof. Ei-ichi Negishi Special Issue).
- H. Fuwa, T. Noguchi, K. Noto, M. Sasaki
Tandem catalysis in domino olefin cross-metathesis/intramolecular oxa-conjugate cyclization: concise synthesis of 2,6-cis-substituted tetrahydropyran derivatives
Organic & Biomolecular Chemistry, 10, 8108-8112 (2012).
- M. Nakajima, H. Fuwa, M. Sasaki
Stereoselective synthesis of the C1–C16 fragment of goniodomin A
Bulletin of the Chemical Society of Japan, 85, 948-956 (2012).
This article was selected as "Selected Paper".
- S. Perez, C. Vale, E. Alonso, H. Fuwa, M. Sasaki, Y. Konno, T. Goto, Y. Suga, M. R. Vieytes, L. M. Botana
Effect of gambierol and its tetracyclic and heptacyclic analogues in cultured cerebellar neurons: A structure–activity relationships study
Chemical Research in Toxicology, 25, 1929-1937 (2012).
- H. Fuwa, K. Ishigai, K. Hashizume, M. Sasaki
Total synthesis and complete stereostructure of gambieric acid A
Journal of the American Chemical Society, 134, 11984-11987 (2012).
This article was featured in SYNFACTS.
- E. Alonso, H. Fuwa, C. Vale, Y. Suga, T. Goto, Y. Konno, M. Sasaki, F. M. LaFerla, M. R. Vieytes, L. Gimenez-Llort, L. M. Botana
Design and synthesis of skeletal analogues of gambierol: Attenuation of amyloid-β and Tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications
Journal of the American Chemical Society, 134, 7467-7479 (2012).
- H. Fuwa, N. Ichinokawa, K. Noto, M. Sasaki
Stereoselective synthesis of 2,6-cis-substituted tetrahydropyrans: Brønsted acid-catalyzed intramolecular oxa-conjugate cyclization of α,β-unsaturated ester surrogates
The Journal of Organic Chemistry, 77, 2588-2607 (2012).
This article was selected as "JOC Featured Article".
This article was featured on the Front Cover.
- H. Fuwa
Total synthesis of tetrahydropyran-containing natural products exploiting intramolecular oxa-conjugate cyclization
Heterocycles, 85, 1255-1298 (2012).
This article was written on invitation from Editor.